You should try burning with diferent programs, wich version of Nero do you have? Burn at low speed, 4X maximum and use good media. To burn a .iso image you can use:
When I first came to this forum, I was using Nero and when I learned about DVD Decrypter, I switched to that. I have never had a problem since. I burned my games at either 2.4 or 4 times speed. I also upgraded my media because I was using Staples DVDs because they were cheap. Now I use Sony and occaisionally I find Verbatim every now and then. Movies will burn fine no matter what brand of media you use. But a PS2 disc is pressed and not burned. Big Difference!
For more help, look at these threads. They should help provide an excellent solution to your problem!