How are you making the ISO file? Are you using the correct LG drive to dump the file? Are you using homebrew to copy the files to SD card? or are you using a downloaded ISO?
It is very possible that you are burning a bad ISO.. When i bought my Wii and games i tried downloaded the games i had and could not get anything to work. Spent weeks downloading ISO files that did not work. Ended up caving and picked up the correct LG drive and rawdump and never had an issue, and wont go back :)
The ISO file size should read exactly 4,699,979,776 bytes. You find the exact size when you right click the ISO and select properties, dont just look at the size below the name of your ISO if you know what i mean. If the size is correct, then check to make sure that your backups are of the same region as your wii(i.e. NTSC backup on NTSCwii...you get the idea..)
I've had the same issues. To cure it just eject the game, wipe off any smudges, and put it back in. After inserting it the game will start where it left off. hope it helps